TCF7 Antibody (YA3979)
(Synonyms: TCF-1)TCF7 Antibody (YA3979) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TCF7.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | N:A FC: 1:200-1:400 | 1:10000 |
Product Details
TCF7 Antibody (YA3979) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TCF7.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 45-50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 42 kDa
Purified recombinant fragment of human TCF7 (AA: 168-358) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TCF7 transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages. Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:It is primarily expressed in T cells. It can also be detected in proliferating intestinal epithelial cells and basal cells of the mammary epithelium.
Induction:By TCF7L2 and CTNNB1 -
Isoforms & Post-Translational Modification
P36402 has 15 isomers: P36402-5: 41552 Da (predicted); P36402-1: 41642 Da (predicted); P36402-2: 30264 Da (predicted); P36402-3: 51991 Da (predicted); P36402-9: 39681 Da (predicted); P36402-10: 28304 Da (predicted); P36402-13: 39933 Da (predicted); P36402-14: 28556 Da (predicted); P36402-15: 40418 Da (predicted); P36402-16: 29041 Da (predicted); P36402-6: 30175 Da (predicted); P36402-7: 41668 Da (predicted); P36402-8: 30291 Da (predicted); P36402-17: 40614 Da (predicted); P36402-18: 44828 Da (predicted).
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Subunit
Binds the armadillo repeat of CTNNB1 and forms a stable complex (PubMed:9488439, PubMed:9783587). Interacts with TLE5, TLE1, TLE2, TLE3 and TLE4 (PubMed:11266540, PubMed:9783587). Interacts with MLLT11 (PubMed:26079538). Long isoform interacts (via N-terminus) with SOX13; inhibits WNT-mediated transcriptional activity (PubMed:17218525, PubMed:20028982). Interacts with DAZAP2 (PubMed:19304756)
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SwissProt ID
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Synonyms
TCF-1
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