Tomoregulin 2 Antibody (YA8530)

Cat. No.: HY-P88846: Data Sheet User Guide for Antibodies
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Tomoregulin 2 Antibody (YA8530) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Tomoregulin 2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Tomoregulin 2 Antibody (YA8530) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Tomoregulin 2.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 41.2 kDa

Species Reactivity

Human, Mouse

SwissProt ID

Q9UIK5

Immunogen

Full length human recombinant protein of human TMEFF2 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2a

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation

Subcellular Localization：Membrane,Membrane,Secreted

Expression：
Tissue_Specificity: Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate
Induction: Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines

Isoforms & Post-Translational Modification：Q9UIK5 has three isomers: Q9UIK5-1: 41428 Da (predicted); Q9UIK5-2: 38132 Da (predicted); Q9UIK5-3: 19472 Da (predicted).
O-glycosylated; contains chondroitin sulfate glycosaminoglycans丨A soluble form (TMEFF2-ECD) is produced by proteolytic shedding

Synonyms

CT120.2; HPP1; TENB2; TPEF; TR; TR-2

Documentation

User Guide for Antibodies (1077 KB)