Tomoregulin 2 Antibody (YA8530)
(Synonyms: CT120.2; HPP1; TENB2; TPEF; TR; TR-2)Tomoregulin 2 Antibody (YA8530) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Tomoregulin 2.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
ICC/IF, FC
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Reactivity :
Human, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
Tomoregulin 2 Antibody (YA8530) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Tomoregulin 2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 41.2 kDa
Full length human recombinant protein of human TMEFF2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Tomoregulin 2 may be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation
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Subcellular Localization
Membrane,Membrane,Secreted
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Expression
Tissue_Specificity: Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate
Induction: Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines -
Isoforms & Post-Translational Modification
Q9UIK5 has three isomers: Q9UIK5-1: 41428 Da (predicted); Q9UIK5-2: 38132 Da (predicted); Q9UIK5-3: 19472 Da (predicted).
O-glycosylated; contains chondroitin sulfate glycosaminoglycans丨A soluble form (TMEFF2-ECD) is produced by proteolytic shedding -
SwissProt ID
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Synonyms
CT120.2; HPP1; TENB2; TPEF; TR; TR-2
Documentation
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