TPRKB Antibody (YA8488)
(Synonyms: CGI-121; CGI121)TPRKB Antibody (YA8488) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TPRKB.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human, Monkey, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:150-500 | 1:100-250 | 1:100 |
Product Details
TPRKB Antibody (YA8488) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TPRKB.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Monkey, Mouse
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Calculated Molecular Weight Predicted band size: 19.5 kDa
Full length human recombinant protein of human TPRKB produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Livraison
Shipping with blue ice.
Background
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Function
TPRKB component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification[1][2].
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Subcellular Localization
Cytoplasm, cytosol,Nucleus
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Expression
Tissue_Specificity: Widely expressed -
Isoforms & Post-Translational Modification
Q9Y3C4 has three isomers: Q9Y3C4-1: 19661 Da (predicted); Q9Y3C4-2: 16093 Da (predicted); Q9Y3C4-3: 23854 Da (predicted).
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Subunit
Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes (PubMed:22912744, PubMed:28805828)
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SwissProt ID
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Synonyms
CGI-121; CGI121
Documentation
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