Trk C Antibody (YA4307)(PBS only)
(Synonyms: TRKC; gp145(trkC))Trk C Antibody (YA4307) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Trk C.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
Trk C Antibody (YA4307) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Trk C.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 94 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 94 kDa
Purified recombinant extracellular fragment of human NTRK3 (aa32-429) fused with hIgGFc tag expressed in HEK293 cells.
affinity purified.
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TrkC (NTRK3) is a receptor tyrosine kinase that functions as a high-affinity receptor for neurotrophin-3 (NT-3) and supports neurotrophin-dependent signaling in neural contexts[1]. Mechanistically, TrkC signaling connects ligand recognition to receptor activation and downstream biological responses, while developmental studies show broad expression in the developing nervous system and selected non-neuronal tissues[2]. In synapse models, postsynaptic TrkC interacts with presynaptic PTPσ to generate bidirectional adhesion and recruitment that are essential for excitatory synapse development[3]. In genetic mouse models, disruption of TrkC eliminates Ia muscle afferent projections, reduces large myelinated axons, and produces abnormal movement and posture, linking NT-3/TrkC signaling to proprioceptive circuit formation[4]. Compared with related Trk isoforms, TrkC shows key ligand and splice-isoform distinctions: TrkC is identified as an NT-3 receptor, and alternative TrkC isoforms display distinct biological properties and substrate specificities[1][5]. Kinase-insert TrkC isoforms show impaired signaling responses, emphasizing isoform selection as a critical experimental variable[6]. For research applications, selective TrkC peptidomimetics can function as agonistic ligands, while NT-3-derived peptidomimetics can antagonize TrkC activation and signaling[7][8].
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Subcellular Localization
Membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:It is widely expressed, but mainly found in neural tissue. Isomer 2 is expressed at a higher level in the human brain than in the fetal brain. -
Isoforms & Post-Translational Modification
Q16288 has 5 isomers: Q16288-1: 94428 Da (predicted); Q16288-2: 68452 Da (predicted); Q16288-3: 92801 Da (predicted); Q16288-4: 93460 Da (predicted); Q16288-5: 91833 Da (predicted).
Ligand-mediated auto-phosphorylation -
Subunit
Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts with PTPRS (PubMed:25385546). Interacts with MAPK8IP3/JIP3 (By similarity)
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SwissProt ID
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Synonyms
TRKC; gp145(trkC)
Documentation
References
[1]. Lamballe F, et al. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell. 1991 Sep 6;66(5):967-79. [Content Brief]
[2]. Tessarollo L, et al. trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development. 1993 Jun;118(2):463-75. [Content Brief]
[3]. Takahashi H, et al. Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex. Neuron. 2011 Jan 27;69(2):287-303. [Content Brief]
[4]. Klein R, et al. Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature. 1994 Mar 17;368(6468):249-51. [Content Brief]
[5]. Lamballe F, et al. trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities. EMBO J. 1993 Aug;12(8):3083-94. [Content Brief]
[6]. Tsoulfas P, et al. TrkC isoforms with inserts in the kinase domain show impaired signaling responses. J Biol Chem. 1996 Mar 8;271(10):5691-7. [Content Brief]
[7]. Zaccaro MC, et al. Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities. Chem Biol. 2005 Sep;12(9):1015-28. [Content Brief]
[8]. Brahimi F, et al. A peptidomimetic of NT-3 acts as a TrkC antagonist. Peptides. 2009 Oct;30(10):1833-9. [Content Brief]
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