TTLL12 Antibody (YA8123)
(Synonyms: dJ526I14.2)TTLL12 Antibody (YA8123) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TTLL12.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human, Dog, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:50-500 | 1:100-250 | 1:100 |
Product Details
TTLL12 Antibody (YA8123) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TTLL12.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 74.4 kDa
Full length human recombinant protein of human TTLL12 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TTLL12 is a Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE[1][2][3].
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Subcellular Localization
Cytoplasm,Midbody,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,Cytoplasm, cytoskeleton, spindle,Nucleus
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Expression
Tissue_Specificity: Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions -
Isoforms & Post-Translational Modification
Q14166: 644 amino acids, molecular weight 74404 Da.
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Subunit
Interacts with MAVS; the interaction prevents MAVS binding to TBK1 and IKBKE (PubMed:28011935)
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SwissProt ID
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Synonyms
dJ526I14.2
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