TYRO3 Antibody (YA4194)
(Synonyms: BYK; Dtk; RSE; Rek; Sky; Tif; Etk-2)TYRO3 Antibody (YA4194) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TYRO3.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
TYRO3 Antibody (YA4194) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TYRO3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 110-140 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 97 kDa
Purified recombinant fragment of human TYRO3 (AA: extra 230-429) expressed in mammalian.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Tyro3 is a member of the TAM (TYRO3, AXL, MER) receptor tyrosine kinase family, which plays critical roles in immune regulation and phagocytosis. It is primarily expressed in the central nervous system and has been implicated in neuroinflammation and neurodegenerative diseases[1]. Tyro3 functions as a receptor for phosphatidylserine (PS), mediating the clearance of apoptotic cells through efferocytosis[2]. This process is essential for maintaining tissue homeostasis and preventing autoimmunity[3]. Recent studies have shown that Tyro3 signaling contributes to microglial quiescence and suppresses pro-inflammatory responses in the brain[3]. Furthermore, dysregulation of Tyro3 has been associated with pathological conditions such as Alzheimer’s disease and multiple sclerosis[4].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:It is abundant in the brain and present in lower amounts in other tissues. -
Subunit
Monomer and homodimer.
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SwissProt ID
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Synonyms
BYK; Dtk; RSE; Rek; Sky; Tif; Etk-2
Documentation
[1]. Bordon Y. Microbiota: Gut bacteria cross malaria. Nat Rev Immunol. 2015 Jan;15(1):1. doi: 10.1038/nri3796. PMID: 25534616. et al. Microbiota: Gut bacteria cross malaria. Nat Rev Immunol. 2015 Jan;15(1):1. [Content Brief]
[2]. Kleaveland B, et al. A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Cell. 2018 Jul 12;174(2):350-362.e17. [Content Brief]
[3]. Kiros M, et al. Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence analysis. Virol J. 2023 Oct 25;20(1):243. [Content Brief]
[4]. Tasaka GI, et al. The Temporal Association Cortex Plays a Key Role in Auditory-Driven Maternal Plasticity. Neuron. 2020 Aug 5;107(3):566-579.e7. [Content Brief]
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