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  5. WWOX Antibody (YA3315)

WWOX Antibody (YA3315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WWOX.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Descripciòn

Descripciòn

WWOX Antibody (YA3315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WWOX.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Peso molecular
Predicted band size: 47 kDa;
Observed band size: 47 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse
SwissProt ID
Gene ID
Immunogen

Recombinant protein of human WWOX
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:200-1:1000
FC
FC: Flow Cytometry
1:200-1:500
IP
IP: Immunoprecipitation
1:20-1:50
Sensitivity Endogenous Pureza Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.
Background
Function：Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm
Subcellular Localization：Cytoplasm; Nucleus; Mitochondrion; Golgi apparatus; Lysosome
Expression：
Tissue_specificity:Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines
Isoforms & Post-Translational Modification：Q9NZC7 has 7 isomers: Q9NZC7-1: 46677 Da (predicted); Q9NZC7-2: 41128 Da (predicted); Q9NZC7-3: 21559 Da (predicted); Q9NZC7-4: 4150 Da (predicted); Q9NZC7-5: 26148 Da (predicted); Q9NZC7-6: 35042 Da (predicted); Q9NZC7-7: 23868 Da (predicted).
Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation;Ubiquitinated when phosphorylated by TNK2, leading to its degradation
Subunit：Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207. Interacts (via WW domain) with VOPP1 (PubMed:30285739)
Database

Entrez Gene: 51741 Human ; 80707 Mouse ; 292041 Rat

SwissProt: Q9NZC7 Human ; Q91WL8 Mouse ;

OMIM: 133239 Human

Research Field

Cell Biology
Synonyms
FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E
Documentación
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

WWOX Antibody (YA3315) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nombre del producto:
WWOX Antibody (YA3315)
Cat. No.:
HY-P83570
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