WWOX Antibody (YA3315)
(Synonyms: FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E)
Based on 1 Customer Validation
WWOX Antibody (YA3315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WWOX.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, FC, IP
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:200-1:1000 | 1:200-1:500 | 1:20-1:50 |
Product Details
WWOX Antibody (YA3315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WWOX.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 47 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 47 kDa
Entrez Gene: 51741 Human ; 80707 Mouse ; 292041 Rat
SwissProt: Q9NZC7 Human ; Q91WL8 Mouse ;
OMIM: 133239 Human
Recombinant protein of human WWOX
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
WWOX is a Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm
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Subcellular Localization
Cytoplasm; Nucleus; Mitochondrion; Golgi apparatus; Lysosome
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Expression
Tissue_specificity:Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines -
Isoforms & Post-Translational Modification
Q9NZC7 has 7 isomers: Q9NZC7-1: 46677 Da (predicted); Q9NZC7-2: 41128 Da (predicted); Q9NZC7-3: 21559 Da (predicted); Q9NZC7-4: 4150 Da (predicted); Q9NZC7-5: 26148 Da (predicted); Q9NZC7-6: 35042 Da (predicted); Q9NZC7-7: 23868 Da (predicted).
Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation;Ubiquitinated when phosphorylated by TNK2, leading to its degradation -
Subunit
Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207. Interacts (via WW domain) with VOPP1 (PubMed:30285739)
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SwissProt ID
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Synonyms
FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E
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Research Field
Cell Biology
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