ZFAND2B Antibody (YA8515)

Cat. No.: HY-P88831: Data Sheet User Guide for Antibodies
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ZFAND2B Antibody (YA8515) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFAND2B.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

ZFAND2B Antibody (YA8515) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFAND2B.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 27.8 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q8WV99

Immunogen

Full length human recombinant protein of human ZFAND2B produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
FC FC: Flow Cytometry	1:100
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)

Subcellular Localization：Endoplasmic reticulum membrane

Expression：Induction: Down-regulated by the miRNA miR-125a-3p in myelo-proliferative neoplasms

Isoforms & Post-Translational Modification：Q8WV99 has two isomers: Q8WV99-1: 28023 Da (predicted); Q8WV99-2: 19306 Da (predicted).
Phosphorylated by MAPK14

Subunit：Binds 'Lys-48'-linked polyubiquitin chains of ubiquitinated proteins (PubMed:24160817)

Synonyms

AIRAPL

Documentation

User Guide for Antibodies (1077 KB)