ZFAND2B Antibody (YA8515)
(Synonyms: AIRAPL)ZFAND2B Antibody (YA8515) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFAND2B.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:100 | 1:100-250 |
Product Details
ZFAND2B Antibody (YA8515) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFAND2B.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 27.8 kDa
Full length human recombinant protein of human ZFAND2B produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ZFAND2B plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway[1].
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Subcellular Localization
Endoplasmic reticulum membrane
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Expression
Induction: Down-regulated by the miRNA miR-125a-3p in myelo-proliferative neoplasms
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Isoforms & Post-Translational Modification
Q8WV99 has two isomers: Q8WV99-1: 28023 Da (predicted); Q8WV99-2: 19306 Da (predicted).
Phosphorylated by MAPK14 -
Subunit
Binds 'Lys-48'-linked polyubiquitin chains of ubiquitinated proteins (PubMed:24160817)
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SwissProt ID
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Synonyms
AIRAPL
Documentation
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