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ZPR1 Antibody (YA6842)

(Synonyms: MGC110983 antibody; Zinc finger protein 259 antibody; Zinc finger protein ZPR1 antibody; ZNF 259 antibody; ZNF259 antibody; ZPR1 antibody; ZPR1_HUMAN antibody; )
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ZPR1 Antibody (YA6842) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ZPR1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, ICC/IF, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • ZPR1 Antibody (YA6842) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
FC Info
FC: Flow Cytometry
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:5000 1:50-1:200 1:1000 1:100

Product Details

Description

ZPR1 Antibody (YA6842) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ZPR1.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 51 kDa
Immunogen

Recombinant protein within human ZPR1 aa 360-459/459.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    ZPR1 acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death[1].

  • Subcellular Localization

    Nucleus,Nucleus, nucleolus,Nucleus, gem,Nucleus, Cajal body,Cytoplasm, perinuclear region,Cytoplasm,Cell projection, axon,Cell projection, growth cone

  • Expression


    Tissue_Specificity: Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients

  • Isoforms & Post-Translational Modification

    ZPR1: 459 amino acids, molecular weight 50925 Da.

  • Subunit

    Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259

  • SwissProt ID

    O75312

  • Gene ID
    8882 [NCBI]
  • Synonyms

    MGC110983 antibody; Zinc finger protein 259 antibody; Zinc finger protein ZPR1 antibody; ZNF 259 antibody; ZNF259 antibody; ZPR1 antibody; ZPR1_HUMAN antibody;

References

[1]. Ito YA, et al. A ZPR1 mutation is associated with a novel syndrome of growth restriction, distinct craniofacial features, alopecia, and hypoplastic kidneys. Clin Genet. 2018 Oct;94(3-4):303-312. [Content Brief]

ZPR1 Antibody (YA6842) Related Classifications

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Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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