Antifungal agent 41

Cat. No.: HY-151439: Ficha de datos Instrucciones de manejo
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Antifungal agent 41 (compound B01) is an antifungal agent. Antifungal agent 41 shows inhibitory effect on Candida albicans in virto and vivo. Antifungal agent 41 can be used for the research of invasive fungal infections.

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Antifungal agent 41 Estructura química

No. CAS : 3033703-21-5

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Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	32.53 μM Compound: B01	Cytotoxicity against human HL-60 cells by MTT assay Cytotoxicity against human HL-60 cells by MTT assay	[PMID: 36057236]
MDA-MB-231	IC₅₀	6.25 μM Compound: B01	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 36057236]
PC-3	IC₅₀	1.43 μM Compound: B01	Cytotoxicity against human PC-3 cells by MTT assay Cytotoxicity against human PC-3 cells by MTT assay	[PMID: 36057236]

In Vitro

Antifungal agent 41 (0.25-128 μg/mL) shows antifungal activities to C.alb, C.alb (sc5314), C.gla, C.par, C.kru, C.zey, C.neo and A.f with MIC values of 2, 1, 8, 2, 8, 0.25, 4 and 1 μg/mL, respectively^[1].
Antifungal agent 41 (0-64 μg/mL; 24 h) shows antifungal activities against pathogenic fluconazole-resistant Candida albicans with MIC values of 2, 8, 4, 2 and 4 μg/mL for strain CaR, 17#, 632, 901 and 904, respectively^[1].
Antifungal agent 41 (0-64 μg/mL; 24 h) shows antifungal activities against Candida albicans with MFC value of 16, 8, 16, >64, 16, 2 and 4 μg/mL for C.alb, C.alb (sc5314), strain CaR, 17#, 632, 901 and 904, respectively^[1].
Antifungal agent 41 (0-1024 μg/mL; 1.5-24 h) inhibits C.alb ATCC SC5314 and CPCC400616 biofilms with SMIC₅₀s of 0.5 μg/mL and 0.5-4 μg/mL, with SMIC₈₀s of 4-32 μg/mL and 2-4 μg/mL, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	HL-60, MDA-MB-231 and PC-3 cell lines
Concentration:	0-100 μM
Incubation Time:	24 h
Result:	Inhibited growth of HL-60, MDA-MB-231 and PC-3 cells with IC₅₀s of 32.53, 6.25 and 1.43 μM, respectively.

In Vivo

Antifungal agent 4 (6-12 mg/kg; i.p. once daily for 5 days) shows in vivo antifungal effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice with C.alb ATCC SC5314 infection^[1]
Dosage:	6 mg/kg and 12 mg/kg
Administration:	Intraperitoneal injection; 6 mg/kg and 12mg/kg once daily; for 5 days
Result:	Significantly reduced the kidney fungal burden of C.alb.

Peso molecular

638.14

Fòrmula

C₂₂H₁₈Cl₄N₄Se₂

No. CAS

3033703-21-5

SMILES

ClC1=CC=C(C([Se][Se]C(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3)CN4C=CN=C4)C(Cl)=C1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Xu H, et al. Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51. Eur J Med Chem. 2022 Aug 28;243:114707. [Content Brief]