Physalaemin
Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity.
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- CAS. Nr.: 2507-24-6
- Formel: C58H84N14O16S
- Molecular Weight:1265.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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NK1R |
Physalaemin (PHY), an undecapeptide with the sequence pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, is a member of the tachykinin family of neuropeptides. PHY is very close to the mammalian tachykinin substance P (SP) in its function and chemical composition, and SP is well studied and characterized[1]. Physalaemin is a bradykinin potentiating peptide (BPP-5a)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2507-24-6
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Molecular Weight 1265.44
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Formel C58H84N14O16S
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SMILES
OC(C=C1)=CC=C1C[C@@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H]3N(CCC3)C([C@H](CC(O)=O)NC([C@H](C)NC([C@H]4NC(CC4)=O)=O)=O)=O)=O)=O)=O)=O
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Sequence
GLP-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2
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Sequence Shortening
{Glp}-ADPNKFYGLM-NH2
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Structure Classification
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Initial Source
African frog Kassina senegalensis
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. [Content Brief]
[2]. Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Physalaemin Related Classifications
HY-P0255 Related Classifications
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