Ramosetron Hydrochloride
Based on 1 publication(s) in Google Scholar
Ramosetron (YM060 free base) Hydrochloride is an orally active 5-HT3 antagonist that improves dysphoria, interference with activity and food avoidance. Ramosetron Hydrochloride is promising for research of irritable bowel syndrome with diarrhea.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.94%
- CAS. Nr.: 132907-72-3
- Formel: C17H18ClN3O
- Molecular Weight:315.80
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Palonosetron hydrochloride
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Publications Citing Use of MedChemExpress (MCE) Ramosetron Hydrochloride
MoreAlle 5-HT Receptor Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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5-HT3 Receptor |
Ramosetron Hydrochloride (1 μM) inhibits 5-HT3 receptor-dependent 5-HT release in guinea pig colonic mucosa[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5-fluorouracil (5-FU) (HY-90006)-induced intestinal mucositis model in mice[2]
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Dosage:0.01-0.1 mg/kg
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Administration:Oral gavage (p.o.), twice daily for 5 days
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Result:Dose-dependently reduced the severity of intestinal mucositis, body weight loss, and diarrhea severity.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 132907-72-3
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Appearance Solid
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Molecular Weight 315.80
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Formel C17H18ClN3O
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Color White to off-white
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SMILES
O=C(C1=CN(C)C2=C1C=CC=C2)[C@@H](C3)CCC4=C3NC=N4.Cl
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Synonyms
YM060
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biol Pharm Bull
Protective Effect of Palonosetron against Cisplatin-Induced Cytotoxicity via Decreased Phosphorylation of p38. [Abstract]2025;48(7):1142-1149. PMID: 40738650
Lösungsmittel & Löslichkeit
H2O : 100 mg/mL (316.66 mM; Need ultrasonic)
DMSO : 32 mg/mL (101.33 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (79.16 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. http://www.drugsupdate.com/generic/view/1111
[2]. Yasuda M, et al. 5-HT₃ receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells. Br J Pharmacol. 2013 Mar;168(6):1388-400. [Content Brief]
[3]. Kojima SI, et al. Investigation of 5-HT3 receptor-triggered serotonin release from guinea-pig isolated colonic mucosa: a role of PYY-containing endocrine cell. Eur J Pharmacol. 2017 Mar 15;799:196-200. [Content Brief]
[4]. Fukudo S, et al. Ramosetron Reduces Symptoms of Irritable Bowel Syndrome With Diarrhea and Improves Quality of Life in Women. Gastroenterology. 2016 Feb;150(2):358-66.e8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.1666 mL | 15.8328 mL | 31.6656 mL | 79.1640 mL |
| 5 mM | 0.6333 mL | 3.1666 mL | 6.3331 mL | 15.8328 mL | |
| 10 mM | 0.3167 mL | 1.5833 mL | 3.1666 mL | 7.9164 mL | |
| 15 mM | 0.2111 mL | 1.0555 mL | 2.1110 mL | 5.2776 mL | |
| 20 mM | 0.1583 mL | 0.7916 mL | 1.5833 mL | 3.9582 mL | |
| 25 mM | 0.1267 mL | 0.6333 mL | 1.2666 mL | 3.1666 mL | |
| 30 mM | 0.1056 mL | 0.5278 mL | 1.0555 mL | 2.6388 mL | |
| 40 mM | 0.0792 mL | 0.3958 mL | 0.7916 mL | 1.9791 mL | |
| 50 mM | 0.0633 mL | 0.3167 mL | 0.6333 mL | 1.5833 mL | |
| 60 mM | 0.0528 mL | 0.2639 mL | 0.5278 mL | 1.3194 mL | |
| 80 mM | 0.0396 mL | 0.1979 mL | 0.3958 mL | 0.9896 mL | |
| 100 mM | 0.0317 mL | 0.1583 mL | 0.3167 mL | 0.7916 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ramosetron Hydrochloride Related Classifications
HY-B0595 Related Classifications
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