132907-72-3
132907-72-3
Chemical Structure
Ramosetron Hydrochloride
Synonym(s): YM060
- CAS No.: 132907-72-3
- Formula:C17H18ClN3O
- Molecular Weight:315.80
IUPAC Name: (R)-(1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzo[d]imidazol-6-yl)methanone hydrochloride
InChIKey: XIXYTCLDXQRHJO-RFVHGSKJSA-N
SMILES: O=C(C1=CN(C)C2=C1C=CC=C2)[C@@H](C3)CCC4=C3NC=N4.Cl
Biological Activity: Ramosetron (YM060 free base) Hydrochloride is an orally active 5-HT3 antagonist that improves dysphoria, interference with activity and food avoidance. Ramosetron Hydrochloride is promising for research of irritable bowel syndrome with diarrhea[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ramosetron Hydrochloride | 99.94% | Ramosetron (YM060 free base) Hydrochloride is an orally active 5-HT3 antagonist that improves dysphoria, interference with activity and food avoidance. Ramosetron Hydrochloride is promising for research of irritable bowel syndrome with diarrhea. | ||||||||||||||||||||
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Ramosetron Hydrochloride (Standard) | 99.88% | Ramosetron (Hydrochloride) (Standard) is the analytical standard of Ramosetron (Hydrochloride). This product is intended for research and analytical applications. 0 | ||||||||||||||||||||
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References
- [1]. http://www.drugsupdate.com/generic/view/1111
- [2]. Yasuda M, et al. 5-HT₃ receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells. Br J Pharmacol. 2013 Mar;168(6):1388-400. [Content Brief]
- [3]. Kojima SI, et al. Investigation of 5-HT3 receptor-triggered serotonin release from guinea-pig isolated colonic mucosa: a role of PYY-containing endocrine cell. Eur J Pharmacol. 2017 Mar 15;799:196-200. [Content Brief]
- [4]. Fukudo S, et al. Ramosetron Reduces Symptoms of Irritable Bowel Syndrome With Diarrhea and Improves Quality of Life in Women. Gastroenterology. 2016 Feb;150(2):358-66.e8. [Content Brief]
