2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor c-Fms
  4. Axl/Mer/CSF1R-IN-1

Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM.

For research use only. We do not sell to patients.

Axl/Mer/CSF1R-IN-1 Chemical Structure

Axl/Mer/CSF1R-IN-1 Chemical Structure

CAS No. : 2394874-60-1

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Axl/Mer/CSF1R-IN-1 Related Antibodies

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Description

Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM[1].

IC50 & Target

Kd: <0.1 μM (Axl, Mer, CSF1R)[1]
In Vitro

Axl/Mer-IN-1 (Compound 1) inhibits cellular Axl activity with an IC50 of <0.5 μM by H1299 Elisa assay. Axl/Mer-IN-1 inhibits cellular CSF1R activity with IC50s of <0.5 μM and <1.0 μM by THP-1 Elisa assay and by M-NFS-60 viability assay, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Axl/Mer/CSF1R-IN-1 Related Antibodies
Molecular Weight

531.48

Formula

C25H24F3N5O5
CAS No.
SMILES

O=C(C1=NN(CC)C(C)=C1OCC(F)(F)F)NC2=NC=C(C=C2)OC3=C4C=C(OC)C(OC)=CC4=NC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Axl/Mer/CSF1R-IN-1 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Axl/Mer/CSF1R-IN-12394874-60-1TAM Receptorc-FmsTyro3AxlMerCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RTHP-1M-NFS-60H1299Inhibitorinhibitorinhibit

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HY-153012
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