Azide-PEG4-VC-PAB-Doxorubicin
Based on 1 Customer Validation
Azide-PEG4-VC-PAB-Doxorubicin is a agent-linker conjugate composed of a cytotoxic anthracycline antibiotic Doxorubicin and a linker Azide-PEG4-VC-PAB to make antibody agent conjugate (ADC). Azide-PEG4-VC-PAB-Doxorubicin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 99.62%
- Formula: C57H75N9O21
- Molecular Weight:1222.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
More
Biological Activity
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Daunorubicins/Doxorubicins |
Antibody-drug conjugates (ADCs) carry a highly potent small-molecule toxin covalently connected on the antibody via a proper linker. For therapeutic ADCs in cancer treatment, the antibody targets specific antigen of tumor cell surface with high binding affinity, thereafter the intact ADC was internalized into the tumor cells with the antigen and digested in the lysosome to release the antitumor toxin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 1222.25
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Formula C57H75N9O21
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Color Orange to red
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SMILES
O[C@@](CC1=C2O)(C[C@@H](C1=C(C(C(C3=C4C=CC=C3OC)=O)=C2C4=O)O)O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC(OCC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)C=C6)=O)C(CO)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (81.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.8182 mL | 4.0908 mL | 8.1816 mL | 20.4541 mL |
| 5 mM | 0.1636 mL | 0.8182 mL | 1.6363 mL | 4.0908 mL | |
| 10 mM | 0.0818 mL | 0.4091 mL | 0.8182 mL | 2.0454 mL | |
| 15 mM | 0.0545 mL | 0.2727 mL | 0.5454 mL | 1.3636 mL | |
| 20 mM | 0.0409 mL | 0.2045 mL | 0.4091 mL | 1.0227 mL | |
| 25 mM | 0.0327 mL | 0.1636 mL | 0.3273 mL | 0.8182 mL | |
| 30 mM | 0.0273 mL | 0.1364 mL | 0.2727 mL | 0.6818 mL | |
| 40 mM | 0.0205 mL | 0.1023 mL | 0.2045 mL | 0.5114 mL | |
| 50 mM | 0.0164 mL | 0.0818 mL | 0.1636 mL | 0.4091 mL | |
| 60 mM | 0.0136 mL | 0.0682 mL | 0.1364 mL | 0.3409 mL | |
| 80 mM | 0.0102 mL | 0.0511 mL | 0.1023 mL | 0.2557 mL |
Azide-PEG4-VC-PAB-Doxorubicin Related Classifications
HY-136288 Related Classifications
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