Biflorin 

Biflorin has antimicrobial, antitumor, antiinflammatory and antimutagenic activities. Biflorin is found in the roots of Capraria biflora L^[1][2][3].

Biflorin (72 h) inhibits tumor cell growth with IC₅₀s ranging from 0.58 μg/mL (NCIH23 cell) to 14.61 μg/mL (MDA-MB-231 cell)^[1].
Biflorin (3 and 6 μg/mL, 24 h) induces apoptosis, internucleosomal DNA fragmentation, mitochondrial depolarization in B16 melanoma cells^[1].
Biflorin inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264.7 macrophages via STAT1 Inactivation, with IC₅₀ s of 51.7 and 37.1 μM, respectively^[2].
Biflorin (5 and 10 μg/mL, 3 h) inhibits H₂O₂-induced oxidative damage by reducing lipid peroxidation and DNA damage in V79 mammalian cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biflorin (25mg/day, i.p., for 10 days) inhibits tumor growth and increases the mean survival rate in B16 melanoma-bearing mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

354.31

C₁₆H₁₈O₉

89701-85-9

O=C1C=C(C)OC2=CC(O)=C([C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C(O)=C12

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Vasconcellos MC, et al. The in-vitro and in-vivo inhibitory activity of biflorin in melanoma. Melanoma Res. 2011 Apr;21(2):106-14.  [Content Brief]

  [2]. Lee HH, et al. Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock. J Nat Prod. 2016 Apr 22;79(4):711-20.  [Content Brief]

  [3]. Vasconcellos MC,et al. Evaluation of the cytotoxic and antimutagenic effects of biflorin, an antitumor 1,4 o-naphthoquinone isolated from Capraria biflora L. Arch Toxicol. 2010 Oct;84(10):799-810.  [Content Brief]