Actin filament-associated protein 1

Definition:

Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.

References:

[1]. Bing Han, et al. Conversion of mechanical force into biochemical signaling. J Biol Chem. 2004 Dec 24;279(52):54793-801. [Content Brief]

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