Actin-related protein 3B

Definition:

Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.

References:

[1]. Nobuko Shindo-Okada, et al. Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. Biochem Biophys Res Commun. 2003 Dec 26;312(4):889-96. [Content Brief]

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