ATP-dependent DNA helicase Q5

Definition:

DNA helicase that plays an important role in DNA replication, transcription and repair. Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability. Associates also with POLR1A and enforces the stability of ribosomal DNA arrays. Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress. Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.

References:

[1]. Rachel Blundred, et al. Human RECQL5 overcomes thymidine-induced replication stress. DNA Repair (Amst). 2010 Sep 4;9(9):964-75. [Content Brief]

[2]. Takashi Tadokoro, et al. Human RECQL5 participates in the removal of endogenous DNA damage. Mol Biol Cell. 2012 Nov;23(21):4273-85. [Content Brief]

[3]. Mahesh Ramamoorthy, et al. The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair. Carcinogenesis. 2013 Oct;34(10):2218-30. [Content Brief]

[4]. Vaclav Urban, et al. RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells. J Cell Biol. 2016 Aug 15;214(4):401-15. [Content Brief]

[5]. Mahesh Ramamoorthy, et al. RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression. Nucleic Acids Res. 2012 Feb;40(4):1621-35. [Content Brief]

[6]. Sybille Schwendener, et al. Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity. J Biol Chem. 2010 May 21;285(21):15739-45. [Content Brief]

[7]. Susanne A Kassube, et al. Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5. Nat Struct Mol Biol. 2013 Jul;20(7):892-9. [Content Brief]

[8]. M Nurul Islam, et al. RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase. Mol Cell Biol. 2010 May;30(10):2460-72. [Content Brief]

[9]. Stefano Di Marco, et al. RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. Mol Cell. 2017 Jun 1;66(5):658-671.e8. [Content Brief]

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