ATP-dependent RNA helicase DHX15

Definition:

RNA helicase involved in mRNA processing and antiviral innate immunity. Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome. Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses. The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu. Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity).

References:

[1]. Hongbo Lu, et al. DHX15 senses double-stranded RNA in myeloid dendritic cells. J Immunol. 2014 Aug 1;193(3):1364-72. [Content Brief]

[2]. Junji Xing, et al. DHX15 is required to control RNA virus-induced intestinal inflammation. Cell Rep. 2021 Jun 22;35(12):109205. [Content Brief]

[3]. Rei Yoshimoto, et al. Isolation and characterization of post-splicing lariat-intron complexes. Nucleic Acids Res. 2009 Feb;37(3):891-902. [Content Brief]

[4]. Meng-Lay Lin, et al. Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis. Cancer Sci. 2009 Aug;100(8):1443-50. [Content Brief]

[5]. Michael K Studer, et al. Structural basis for DEAH-helicase activation by G-patch proteins. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7159-7170. [Content Brief]

[6]. Kenta Mosallanejad, et al. The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses. Sci Signal. 2014 Apr 29;7(323):ra40. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.