Beta-1,4 N-acetylgalactosaminyltransferase 1

Definition:

Involved in the biosynthesis of gangliosides GM2, GD2, GT2 and GA2 from GM3, GD3, GT3 and GA3, respectively.

References:

[1]. S Ruan, et al. Analysis of melanoma cells stably transfected with beta 1,4GalNAc transferase (GM2/GD2 synthase) cDNA: relative glycosyltransferase levels play a dominant role in determining ganglioside expression. Arch Biochem Biophys. 1995 Oct 20;323(1):11-8. [Content Brief]

[2]. Y Nagata, et al. Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides. J Biol Chem. 1992 Jun 15;267(17):12082-9. [Content Brief]

[3]. S Yamashiro, et al. Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells. J Biol Chem. 1995 Mar 17;270(11):6149-55. [Content Brief]

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