Calcium-activated chloride channel regulator 1

Definition:

May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.

References:

[1]. S A Bustin, et al. Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer. DNA Cell Biol. 2001 Jun;20(6):331-8. [Content Brief]

[2]. Makoto Hoshino, et al. Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway. Am J Respir Crit Care Med. 2002 Apr 15;165(8):1132-6. [Content Brief]

[3]. Zeynep Yurtsever, et al. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. J Biol Chem. 2012 Dec 7;287(50):42138-49. [Content Brief]

[4]. A D Gruber, et al. Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins. Genomics. 1998 Dec 1;54(2):200-14. [Content Brief]

[5]. Masao Toda, et al. A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma. J Allergy Clin Immunol. 2002 Feb;109(2):246-50. [Content Brief]

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