Carbonyl reductase [NADPH] 3

Definition:

Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified.

References:

[1]. Ewa S Pilka, et al. Structural basis for substrate specificity in human monomeric carbonyl reductases. PLoS One. 2009 Oct 20;4(10):e7113. [Content Brief]

[2]. Takeshi Miura, et al. Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. Mol Cell Biochem. 2008 Aug;315(1-2):113-21. [Content Brief]

[3]. Sukhwinder S Lakhman, et al. Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3). Drug Metab Dispos. 2005 Feb;33(2):254-7. [Content Brief]

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