Centromere protein Q

Definition:

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores.

References:

[1]. James Bancroft, et al. Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways. J Cell Sci. 2015 Jan 1;128(1):171-84. [Content Brief]

[2]. Masahiro Okada, et al. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat Cell Biol. 2006 May;8(5):446-57. [Content Brief]

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