Cleavage and polyadenylation specificity factor subunit 7

Definition

Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates.

References:

[1]. Andreas R Gruber, et al. Cleavage factor Im is a key regulator of 3' UTR length. RNA Biol. 2012 Dec;9(12):1405-12. [Content Brief]

[2]. Yong Zhu, et al. Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. Mol Cell. 2018 Jan 4;69(1):62-74.e4. [Content Brief]

[3]. Stefania Millevoi, et al. An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries. EMBO J. 2006 Oct 18;25(20):4854-64. [Content Brief]

[4]. Sol Kim, et al. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. Genes Cells. 2010 Sep 1;15(9):1003-13. [Content Brief]

[5]. U Rüegsegger, et al. Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors. J Biol Chem. 1996 Mar 15;271(11):6107-13. [Content Brief]

生物医学辞典

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