Coiled-coil domain-containing protein 8
Definition:
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome.
References:
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[1]. Jun Yan, et al. The 3M complex maintains microtubule and genome integrity. Mol Cell. 2014 Jun 5;54(5):791-804. [Content Brief]
[2]. Zhijun Li, et al. CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. Mol Cell. 2014 Jun 5;54(5):805-19. [Content Brief]
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