CXXC-type zinc finger protein 5

Definition:

May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG.

References:

[1]. Chao Xu, et al. DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. Structure. 2018 Jan 2;26(1):85-95.e3. [Content Brief]

[2]. Min ZHANG, et al. The CXXC finger 5 protein is required for DNA damage-induced p53 activation. Sci China C Life Sci. 2009 Jun;52(6):528-38. [Content Brief]

[3]. Frédéric Pendino, et al. Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. Blood. 2009 Apr 2;113(14):3172-81. [Content Brief]

[4]. Siddhesh Aras, et al. Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. Nucleic Acids Res. 2013 Feb 1;41(4):2255-66. [Content Brief]

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