Cysteine protease ATG4B

[1]. Isei Tanida, et al. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. J Biol Chem. 2004 Aug 27;279(35):36268-76. [Content Brief]

[2]. Min Li, et al. A high-throughput FRET-based assay for determination of Atg4 activity. Autophagy. 2012 Mar;8(3):401-12. [Content Brief]

[3]. Zhifen Yang, et al. ATG4B (Autophagin-1) phosphorylation modulates autophagy. J Biol Chem. 2015 Oct 30;290(44):26549-61. [Content Brief]

[4]. Aimin Yang, et al. Distinct Mechanisms for Processing Autophagy Protein LC3-PE by RavZ and ATG4B. Chembiochem. 2020 Dec 1;21(23):3377-3382. [Content Brief]

[5]. D Bosc, et al. A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B. Sci Rep. 2018 Aug 3;8(1):11653. [Content Brief]

[6]. Chih-Wen Shu, et al. Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4). Autophagy. 2010 Oct;6(7):936-47. [Content Brief]

[7]. Karlina J Kauffman, et al. Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases. Autophagy. 2018;14(6):992-1010. [Content Brief]

[8]. Joanne Durgan, et al. Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine. Mol Cell. 2021 May 6;81(9):2031-2040.e8. [Content Brief]

[9]. N Pengo, et al. A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B. Nat Commun. 2017 Aug 18;8(1):294. [Content Brief]

[10]. Yukiko Kabeya, et al. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci. 2004 Jun 1;117(Pt 13):2805-12. [Content Brief]

[11]. Yoon Kyung Jo, et al. O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity. Oncotarget. 2016 Aug 30;7(35):57186-57196. [Content Brief]

[12]. Ruth Scherz-Shouval, et al. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J. 2007 Apr 4;26(7):1749-60. [Content Brief]

[13]. Alexander Agrotis, et al. Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells. Autophagy. 2019 Jun;15(6):976-997. [Content Brief]

[14]. Kenji Satoo, et al. The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J. 2009 May 6;28(9):1341-50. [Content Brief]

[15]. Thanh Ngoc Nguyen, et al. ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system. Mol Cell. 2021 May 6;81(9):2013-2030.e9. [Content Brief]

[16]. Yazi Li, et al. Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia. Autophagy. 2017 Jul 3;13(7):1145-1160. [Content Brief]

[17]. Min Li, et al. Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates. J Biol Chem. 2011 Mar 4;286(9):7327-38. [Content Brief]

[18]. Tianzhi Huang, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32(6):840-855.e8. [Content Brief]

[19]. Niccolo Pengo, et al. Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells. Front Cell Dev Biol. 2018 Nov 1;6:148. [Content Brief]

[20]. Mads Skytte Rasmussen, et al. ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8. Autophagy. 2017 May 4;13(5):834-853. [Content Brief]

[21]. Alexander Agrotis, et al. Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins. J Biol Chem. 2019 Aug 23;294(34):12610-12621. [Content Brief]