Cytosolic carboxypeptidase 1

Definition:

Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis.

References:

[1]. Vandana Shashi, et al. Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration. EMBO J. 2018 Dec 3;37(23):e100540. [Content Brief]

[2]. Iryna Berezniuk, et al. Cytosolic carboxypeptidase 1 is involved in processing α- and β-tubulin. J Biol Chem. 2012 Feb 24;287(9):6503-17. [Content Brief]

[3]. Buqing Ye, et al. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261. [Content Brief]

[4]. Iryna Berezniuk, et al. Cytosolic carboxypeptidase 5 removes α- and γ-linked glutamates from tubulin. J Biol Chem. 2013 Oct 18;288(42):30445-30453. [Content Brief]

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