DNA cross-link repair 1A protein
Definition:
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem).
References:
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[1]. Seydina M Diene, et al. Human metallo-β-lactamase enzymes degrade penicillin. Sci Rep. 2019 Aug 21;9(1):12173. [Content Brief]
[2]. Shamima Akhter, et al. Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Mol Cell Biol. 2004 Dec;24(23):10448-55. [Content Brief]
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