2. Biology Dictionary
  3. E3 ubiquitin-protein ligase DCST1

E3 ubiquitin-protein ligase DCST1

Definition:

E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. Essential sperm cell-surface protein required for sperm-egg fusion and fertilization (By similarity).

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