E3 ubiquitin-protein ligase RNF19B

Definition:

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death.

References:

[1]. Julie M Fortier, et al. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. J Immunol. 2006 Jun 1;176(11):6454-63. [Content Brief]

[2]. M Kozlowski, et al. NK lytic-associated molecule: a novel gene selectively expressed in cells with cytolytic function. J Immunol. 1999 Aug 15;163(4):1775-85. [Content Brief]

[3]. Masayuki Kaneko, et al. Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation. Sci Rep. 2016 Aug 3;6:30955. [Content Brief]

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