E3 ubiquitin-protein ligase RNF220
Definition:
E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling. Plays a critical role in the regulation of nuclear lamina.
References:
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[1]. Antonella Sferra, et al. Biallelic mutations in RNF220 cause laminopathies featuring leukodystrophy, ataxia and deafness. Brain. 2021 Nov 29;144(10):3020-3035. [Content Brief]
[2]. Pengcheng Ma, et al. The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of β-catenin. Mol Cell Biol. 2014 Dec 1;34(23):4355-66. [Content Brief]
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