E3 ubiquitin-protein ligase TRIM22

Definition:

Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.

References:

[1]. Zhijian Duan, et al. Identification of TRIM22 as a RING finger E3 ubiquitin ligase. Biochem Biophys Res Commun. 2008 Sep 26;374(3):502-6. [Content Brief]

[2]. Stephen D Barr, et al. The interferon response inhibits HIV particle production by induction of TRIM22. PLoS Pathog. 2008 Feb 29;4(2):e1000007. [Content Brief]

[3]. Patrick Eldin, et al. TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus. J Gen Virol. 2009 Mar;90(Pt 3):536-545. [Content Brief]

[4]. Bo Gao, et al. Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain. Hepatology. 2009 Aug;50(2):424-33. [Content Brief]

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