Ectopic P granules protein 5 homolog

Definition:

Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located.

References:

[1]. Ye Tian, et al. C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell. 2010 Jun 11;141(6):1042-55. [Content Brief]

[2]. Thomas Cullup, et al. Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy. Nat Genet. 2013 Jan;45(1):83-7. [Content Brief]

[3]. E Piano Mortari, et al. The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity. Autophagy. 2018;14(1):22-37. [Content Brief]

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