Elongator complex protein 6

Definition:

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Involved in cell migration (By similarity).

References:

[1]. Udit Dalwadi, et al. Structural insights into the function of Elongator. Cell Mol Life Sci. 2018 May;75(9):1613-1622. [Content Brief]

[2]. Pierre Close, et al. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. J Biol Chem. 2012 Sep 21;287(39):32535-45. [Content Brief]

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