Elongin-A
Definition:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).; As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A.
References:
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[1]. T Aso, et al. A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin. Gene. 1996 Feb 12;168(2):277-8. [Content Brief]
[2]. Michelle Harreman, et al. Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20705-10. [Content Brief]
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