Endonuclease 8-like 2

Definition:

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

References:

[1]. Aditi Das, et al. Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein. J Biol Chem. 2004 Nov 5;279(45):47132-8. [Content Brief]

[2]. Kishor K Bhakat, et al. Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity. Nucleic Acids Res. 2004 Jun 2;32(10):3033-9. [Content Brief]

[3]. Hong Dou, et al. Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. J Biol Chem. 2003 Dec 12;278(50):49679-84. [Content Brief]

[4]. Tapas K Hazra, et al. Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions. J Biol Chem. 2002 Aug 23;277(34):30417-20. [Content Brief]

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