Endoplasmic reticulum junction formation protein lunapark

Definition:

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network. May be involved in limb development (By similarity). Is involved in central nervous system development.

References:

[1]. Koko Moriya, et al. Protein N-myristoylation plays a critical role in the endoplasmic reticulum morphological change induced by overexpression of protein Lunapark, an integral membrane protein of the endoplasmic reticulum. PLoS One. 2013 Nov 4;8(11):e78235. [Content Brief]

[2]. Tom Shemesh, et al. A model for the generation and interconversion of ER morphologies. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5243-51. [Content Brief]

[3]. Shuliang Chen, et al. Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):418-23. [Content Brief]

[4]. Songyu Wang, et al. Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network. Elife. 2016 Sep 13;5:e18605. [Content Brief]

[5]. Martin W Breuss, et al. Mutations in LNPK, Encoding the Endoplasmic Reticulum Junction Stabilizer Lunapark, Cause a Recessive Neurodevelopmental Syndrome. Am J Hum Genet. 2018 Aug 2;103(2):296-304. [Content Brief]

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