Endosomal transmembrane epsin interactor 1

Definition:

Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway.

References:

[1]. Takumi Tsunoda, et al. ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer. EMBO Rep. 2022 Feb 3;23(2):e51182. [Content Brief]

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