ER degradation-enhancing alpha-mannosidase-like protein 1

Definition:

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

References:

[1]. Maria Kosmaoglou, et al. A dual role for EDEM1 in the processing of rod opsin. J Cell Sci. 2009 Dec 15;122(Pt 24):4465-72. [Content Brief]

[2]. Maurizio Molinari, et al. Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle. Science. 2003 Feb 28;299(5611):1397-400. [Content Brief]

[3]. James H Cormier, et al. EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. Mol Cell. 2009 Jun 12;34(5):627-33. [Content Brief]

[4]. Satoshi Ninagawa, et al. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. J Cell Biol. 2014 Aug 4;206(3):347-56. [Content Brief]

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