Estrogen receptor α (ER)

Definition:

Estrogen receptor α (ER) is a ligand dependent transcription factor that directly binds specific estrogen responsive elements, thus regulating the transcription of estrogen sensitive genes.ERα has also been shown to be associated with the plasma membrane (membrane associated ERα, mERα), concentrated in lipid rafts, plasma membrane microdomains with a distinct lipid composition, where it transduces membrane-initiated estrogen-dependent activation of the Mitogen-activated protein kinase (MAPK) signaling pathway.

References:

[1]. Pagano MT, et al. A Role for Estrogen Receptor alpha36 in Cancer Progression. Front Endocrinol (Lausanne). 2020 Jul 31;11:506. [Content Brief]

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