ETS-related transcription factor Elf-3

Definition:

Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).

References:

[1]. J Chang, et al. Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous TGF-beta type II receptor expression and restores the TGF-beta signaling pathway in Hs578t human breast cancer cells. Oncogene. 2000 Jan 6;19(1):151-4. [Content Brief]

[2]. S H Park, et al. Sequence-specific enhancer binding protein is responsible for the differential expression of ERT/ESX/ELF-3/ESE-1/jen gene in human gastric cancer cell lines: Implication for the loss of TGF-beta type II receptor expression. Oncogene. 2001 Mar 8;20(10):1235-45. [Content Brief]

[3]. Richard M Neve, et al. Identification of an epithelial-specific enhancer regulating ESX expression. Gene. 2006 Feb 15;367:118-25. [Content Brief]

[4]. C H Chang, et al. ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis. Oncogene. 1997 Apr 3;14(13):1617-22. [Content Brief]

[5]. Franck T Grall, et al. The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes. FEBS J. 2005 Apr;272(7):1676-87. [Content Brief]

[6]. F H Brembeck, et al. Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation. Oncogene. 2000 Apr 6;19(15):1941-9. [Content Brief]

[7]. Courtney Brown, et al. ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. J Biol Chem. 2004 Mar 26;279(13):12794-803. [Content Brief]

[8]. P Oettgen, et al. Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family. Mol Cell Biol. 1997 Aug;17(8):4419-33. [Content Brief]

[9]. Pepper J Schedin, et al. ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells. Oncogene. 2004 Mar 4;23(9):1766-79. [Content Brief]

[10]. Kristin L Eckel, et al. The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression. DNA Cell Biol. 2003 Feb;22(2):79-94. [Content Brief]

[11]. Adriana Cabral, et al. Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation. J Biol Chem. 2003 May 16;278(20):17792-9. [Content Brief]

[12]. Jason D Prescott, et al. The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism. Mol Cell Biol. 2004 Jun;24(12):5548-64. [Content Brief]

[13]. S G Choi, et al. A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming growth factor-beta type II receptor. J Biol Chem. 1998 Jan 2;273(1):110-7. [Content Brief]

[14]. John H Kwon, et al. ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells. J Biol Chem. 2003 Jan 10;278(2):875-84. [Content Brief]

[15]. S Rudders, et al. ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene. J Biol Chem. 2001 Feb 2;276(5):3302-9. [Content Brief]

[16]. J M Andreoli, et al. The expression of a novel, epithelium-specific ets transcription factor is restricted to the most differentiated layers in the epidermis. Nucleic Acids Res. 1997 Nov 1;25(21):4287-95. [Content Brief]

[17]. C H Chang, et al. Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP). Oncogene. 1999 Jun 24;18(25):3682-95. [Content Brief]

[18]. Hong Wang, et al. Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. J Biol Chem. 2004 Jun 11;279(24):25241-50. [Content Brief]

[19]. Yoshiki Kohno, et al. Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3. J Biol Chem. 2006 Dec 15;281(50):38941-50. [Content Brief]

[20]. M J Tymms, et al. A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer. Oncogene. 1997 Nov 13;15(20):2449-62. [Content Brief]

[21]. Sekhar P M Reddy, et al. Interplay between proximal and distal promoter elements is required for squamous differentiation marker induction in the bronchial epithelium: role for ESE-1, Sp1, and AP-1 proteins. J Biol Chem. 2003 Jun 13;278(24):21378-87. [Content Brief]

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