Eukaryotic translation initiation factor 4E transporter

Definition:

EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression. Required for the formation of P-bodies. Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay. Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism.

References:

[1]. Jo-Hsi Huang, et al. Dual mechanisms regulate the nucleocytoplasmic localization of human DDX6. Sci Rep. 2017 Feb 20;7:42853. [Content Brief]

[2]. Felix Räsch, et al. 4E-T-bound mRNAs are stored in a silenced and deadenylated form. Genes Dev. 2020 Jun 1;34(11-12):847-860. [Content Brief]

[3]. Maria A Ferraiuolo, et al. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. J Cell Biol. 2005 Sep 12;170(6):913-24. [Content Brief]

[4]. Clément Chapat, et al. Cap-binding protein 4EHP effects translation silencing by microRNAs. Proc Natl Acad Sci U S A. 2017 May 23;114(21):5425-5430. [Content Brief]

[5]. Anastasiia Kamenska, et al. The DDX6-4E-T interaction mediates translational repression and P-body assembly. Nucleic Acids Res. 2016 Jul 27;44(13):6318-34. [Content Brief]

[6]. J Dostie, et al. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. EMBO J. 2000 Jun 15;19(12):3142-56. [Content Brief]

[7]. Anastasiia Kamenska, et al. Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing. Nucleic Acids Res. 2014 Mar;42(5):3298-313. [Content Brief]

[8]. Marie Cargnello, et al. Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly. Mol Cell Biol. 2012 Nov;32(22):4572-84. [Content Brief]

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