Glycylpeptide N-tetradecanoyltransferase 2

Definition

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3'. Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle.

References:

[1]. D K Giang, et al. A second mammalian N-myristoyltransferase. J Biol Chem. 1998 Mar 20;273(12):6595-8. [Content Brief]

[2]. Tatsiana Kosciuk, et al. NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nat Commun. 2020 Feb 26;11(1):1067. [Content Brief]

[3]. Emmanuelle Thinon, et al. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat Commun. 2014 Sep 26;5:4919. [Content Brief]

生物医学辞典

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