Hematopoietically-expressed homeobox protein HHEX
Definition:
Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). May play a role in hematopoietic differentiation.
References:
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[1]. Vanessa Marfil, et al. Interaction between Hhex and SOX13 modulates Wnt/TCF activity. J Biol Chem. 2010 Feb 19;285(8):5726-37. [Content Brief]
[2]. F K Bedford, et al. HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. Nucleic Acids Res. 1993 Mar 11;21(5):1245-9. [Content Brief]
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