Histone-lysine N-methyltransferase NSD2
Definition:
References:
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[1]. Alex J Kuo, et al. NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell. 2011 Nov 18;44(4):609-20. [Content Brief]
[2]. Heidi Rye Hudlebusch, et al. Identification of ID-1 as a potential target gene of MMSET in multiple myeloma. Br J Haematol. 2005 Sep;130(5):700-8. [Content Brief]
[3]. Lenan Zhuang, et al. Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun. 2018 May 4;9(1):1796. [Content Brief]
[4]. Dominic Tisi, et al. Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives. ACS Chem Biol. 2016 Nov 18;11(11):3093-3105. [Content Brief]
[5]. Yan Li, et al. The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. J Biol Chem. 2009 Dec 4;284(49):34283-95. [Content Brief]
[6]. Ji-Young Kim, et al. Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity. Mol Cell Biol. 2008 Mar;28(6):2023-34. [Content Brief]
[7]. Paolo Zanoni, et al. Loss-of-function and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct developmental phenotype. Genet Med. 2021 Aug;23(8):1474-1483. [Content Brief]
[8]. C G Garlisi, et al. A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription. Am J Respir Cell Mol Biol. 2001 Jan;24(1):90-98. [Content Brief]
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