Ichthyosis vulgaris

Definition:

Ichthyosis vulgaris is one of the most common genetic keratinization disorder characterized by follicular keratosis and grey scaling on the flexor limbs. It is caused by defective synthesis of filaggrin that leads to reduction of keratohyalin granules in epidermis. The condition is inherited in an autosomal dominant pattern.

References:

[1]. Frances J D Smith, et al. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet. 2006 Mar;38(3):337-42. [Content Brief]

[2]. Masashi Akiyama, et al. An update on molecular aspects of the non-syndromic ichthyoses. Exp Dermatol. 2008 May;17(5):373-82. [Content Brief]

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