Immediate early response gene 2 protein

Definition:

DNA-binding protein that seems to act as a transcription factor. Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis.

References:

[1]. Tomoyuki Takaya, et al. Functional analyses of immediate early gene ETR101 expressed in yeast. Biosci Biotechnol Biochem. 2009 Jul;73(7):1653-60. [Content Brief]

[2]. A Neeb, et al. The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients. Oncogene. 2012 Aug 16;31(33):3796-806. [Content Brief]

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