Immune checkpoint blockade (ICB)

Definition:

Immune checkpoint blocking is a tumor therapy based on the activation mechanism of immune cell T cells. The immune checkpoint consists of programmed death receptors and their ligands expressed on the surface of T cells and on the surface of tumor and myeloid suppressor cells, respectively. When they bind, they can cause T cell exhaustion and tumor killing ability, causing tumor cells to escape. Therefore, blocking therapy is used to inhibit the combination of the two, thus increasing the host immune system's aggression against tumor cells.

References:

[1]. Morad G, et al. Hallmarks of response, resistance, and toxicity to immune checkpoint blockade. Cell. 2021 Oct 14;184(21):5309-5337. [Content Brief]

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